About Us
We are a consultancy company based in Australia
Extensive pharmacometrics expertise
Expertise in population pharmacokinetics, pharmacokinetic-pharmacodynamic and exposure-response modelling and simulation in a variety of therapeutic areas
High quality quantitative reports
We assist our clients to prepare high quality quantitative clinical pharmacology modelling and simulation reports to support submissions to pharmaceutical regulators.
A consultant you can trust
Principal consultant, Helen Kastrissios, PhD, is a pharmacometrician with over 20 years of experience in applying quantitative clinical pharmacology methods to support regulatory submissions.
Selected Publications
Kazutaka Y, Kobayashi Y, Endo S, Fukae M, Hennig S, Kastrissios H, Kamiyama E, Garimella T, Abutarif M. Trastuzumab Deruxtecan Dosing in Human Epidermal Growth Factor Receptor 2-Positive Gastric Cancer: Population Pharmacokinetic Modeling and Exposure-Response Analysis. J Clin. Pharmacol. 2023; 63 (11):1232-1243
Kazutaka Y, Fukae M, Kastrissios H, Wada R, Shimizu T, Ishizuka H. Population pharmacokinetics of esaxerenone, a novel non-steroidal mineralocorticoid receptor blocker, in patients with essential hypertension, patients with diabetic nephropathy, and healthy volunteers. Drug Metab Pharmacokin. 2023; 52(100516):1-11
Zheng B, Duffy D, Tricoci P, Kastrissios H, Pfister M, Wright SD, Gille A, Tortorici M. Pharmacometric analyses to characterize the effect of CSL112 on apolipoprotein A-I and cholesterol efflux capacity in acute myocardial infarction patients. British J. Clin. Pharmacol. 2021; 87(6):2558 – 2571
Dykstra K, Mehrotra N, Tornøe CW, Kastrissios H, Patel B, Al-Huniti N, Jadhav P, Wang Y, Byon W. Reporting guidelines for population pharmacokinetic analyses. J. Pharmacokinet. Pharmacodyn. 2015; 42(3):301-14
Services
Assisting Pharmaceutical Organisations
with their Pharmacometric Modeling and Reporting Needs. Our extensive pharmacometrics experience across a variety of therapeutic areas allow us to provide:
- Tailored advice on Population PK and PK/PD modelling methods
- Preparation of Population PK and PK/PD Regulatory Reports
